Capa do livro: In vitro drug release assays from nanostructured systems: <Br>Practical Aspects and Kinetic Models

In vitro drug release assays from nanostructured systems:
Practical Aspects and Kinetic Models

Autores: Nágila Maria Pontes Silva Ricardo - Louhana Moreira Rebouças (Orgs.)

This book explores the practical and experimental aspects of in vitro drug release assays, focusing on technical details. It presents examples of in vitro release assays performed with drugs encapsulated in nanostructured systems such as nanoemulsions, nanoemulgels, liposomes, solid lipid nanoparticles, and polymeric nanocapsules. The apparatus used, the composition of receptor media, and the types of membranes employed in these experiments are described in detail. Additionally, the mathematical treatment of raw data generated during drug quantification is discussed to ensure reliable results. The application of kinetic models to describe release profiles is also examined, providing insight into the mechanisms behind controlled drug release.
This content is intended for researchers, students, and professionals in the chemical and pharmaceutical fields. The work was developed as part of the course Topics in Physical Chemistry III on the theme Kinetic Models of In Vitro Release of Nanoencapsulated Drugs, within the Postgraduate Program in Chemistry at the Federal University of Ceará (UFC). This project was financially supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) through the Programa de Excelência Acadêmica (PROEX), Brazil.

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Editora: EDITORA CRV
ISBN:978-65-251-7582-9
ISBN DIGITAL:978-65-251-7583-6
DOI: 10.24824/978652517582.9
Ano de edição: 2025
Distribuidora: EDITORA CRV
Número de páginas: 134
Formato do Livro: 14x21 cm
Número da edição:1

  • PREFACE - 11
  • CHAPTER I INTRODUCTION TO DRUG RELEASE FROM NANOSTRUCTURED SYSTEMS - 13
  • CHAPTER II RECEPTOR MEDIA UTILISED IN IN VITRO RELEASE STUDIES - 35
  • CHAPTER III TRANSDERMAL PENETRATION AND MEMBRANES USED AS SKIN MODELS IN DRUG RELEASE AND PERMEATION STUDIES - 53
  • CHAPTER IV PROCESSING OF RAW DATA OBTAINED FROM IN VITRO RELEASE STUDIES - 77
  • CHAPTER V KINETIC MODELING FOR IN VITRO DRUG RELEASE FROM NANOSTRUCTURED SYSTEMS - 97
  • POSTFACE - 127
  • INDEX - 129
  • AUTHORS - 131

ORGANIZERS

NÁGILA MARIA PONTES SILVA RICARDO

Is a Professor in the Department of Organic and Inorganic Chemistry at the Federal University of Ceará (UFC) and the Group Leader of the Laboratory of Polymers and Materials Innovation (LabPIM). N. Ricardo completed in 1996 her PhD at the University of Manchester, Manchester (United Kingdom), in Polymer Sciences, followed by a Postdoctoral position at the same university. Her recent work has focus on the synthesis of nanosystems and magnetic nanocomposites based on polysaccharides, block copolymers systems towards the solubilisation/delivery of drugs and bioactives as anticancer strategy as well as biolubricants from Brazilian oleaginous species. She coordinated many projects (Germany, France, Portugal, and Brazil) and is the author of more than 230 publications and 10 patents.

LOUHANA MOREIRA REBOUÇAS

Is a PhD in Chemistry and Postdoctoral internship from the Postgraduate Program in Chemistry at the Federal University of Ceará (UFC). Technician in Chemistry at the Federal Institute of Education, Science and Technology of Ceará (IFCE) and full member of the Brazilian Society of Nanomedicine. Currently developing new systems for the delivery of hydrophobic drugs. Collaborating lecturer of the Postgraduate Program in Chemistry at UFC, teaching the discipline of Kinetics of In Vitro Release Models of Nanoencapsulated Drugs.

AUTHORS

ANDERSON FREITAS DE SOUSA

Holds a degree in Chemistry from the State University of Ceará (UECE), a specialization in Chemistry Teaching at the Cândido Mendes University and a Master degree in Chemistry at the Federal University of Ceará (UFC). He is currently a PhD student in Chemistry at UFC, with an emphasis on the development of polymeric materials and the microencapsulation of antineoplastic drugs. Since 2014, he has been working as a teacher in the state education system of Ceará. He is the husband of Dieyna Gomes and the father of Maria Luísa.

ANTONIO LUCAS FREITAS SILVA

Holds a degree in Chemistry from the Federal Institute of Education, Science and Technology of Ceará (IFCE), Maracanaú Campus. He was a scientific initiation scholarship holder and developed research in the area of ??phytochemistry. He worked as a teacher in public and private schools. He is currently a MSc in the Postgraduate Program in Chemistry (PGQUIM) at the Federal University of Ceará (UFC).

ARCELINA PACHECO CUNHA

Is a PhD in Chemistry, with an emphasis on Biopolymers applied to Biomedicine and Post-doctoral (PNPD/CAPES) with an emphasis on Polymer Chemistry and Nanotechnology. She is currently a research fellow at the Complex of Equipment and Multi-User Laboratories and Advanced Microscopy (CELMMA) at the State University of Ceará (UECE) working on the development and characterization of polymeric nanocomposites.

CAROLINE DE GOES SAMPAIO

Is a PhD in Chemistry from the Federal University of Ceará (UFC), in Post-doctoral internship in the Postgraduate Program in Chemistry at the Federal University of Ceará (UFC). Professor at the Federal Institute of Education, Science and Technology (IFCE), develops research in ??natural products and nanotechnology, with an emphasis on materials with pharmacological actions.

CRISTINE SOARES VIDAL DE MENEZES

Holds a Bachelor's and Master degree in Chemistry from the Federal University of Ceará (UFC). She is currently a PhD student in Chemistry at the same university, with a sandwich period at the Max Planck Institute for Polymer Research in Mainz, Germany. She has experience in the field of chemistry with a focus on polymers, working mainly on the following topics: nanoemulsions, nanocapsules, polysaccharides and hydrophobic drugs.

DAVID THOMAS DUARTE ARRUDA

Holds a degree in Chemistry from the Federal University of Ceará, Master degree in Chemistry with emphasis in Organic Chemistry, developing biofuel synthesis with brazilian oleaginous species from the Federal University of Ceará. PhD student in Chemistry. He has experience in the development of sustainable biolubricants from Brazilian oleaginous species.

DEYSE DE SOUSA MAIA

Holds a Master degree in Chemistry from the Federal University of Ceará. She has experience in the area of ??Chemistry, with an emphasis on Solid Lipid Nanoparticles for pharmaceutical and cosmetic applications. She works at the Laboratory of Polymers and Materials Innovations (LabPIM) at the Federal University of Ceará. She is currently a laboratory technician in the Department of Soil Sciences at the Federal University of Ceará (UFC) and a PhD student in the Postgraduate Program in Chemistry at the Federal University of Ceará (UFC).

FRANCISCO LEONARDO MORENO MARTINS

Is a petrochemical technician (2018) and holds a degree in Chemistry (2024) from the Federal Institute of Education, Science and Technology of Ceará (IFCE). He is currently a Master student in Chemistry at the Federal University of Ceará (UFC). He has experience in chemistry with a focus on biofuels, bioadditives and nanoemulsions.

MARLON ERICK PEREIRA ROSA

Holds a Bachelor's degree in Chemistry with Summa Cum Laude diploma from the Federal University of Ceará (UFC). Master in Chemistry from the Federal University of Ceará (UFC), with an emphasis on polymeric nanostructured materials for drug delivery.