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Prophylactic and therapeutic vaccines against hpv and associated cancers

Autores: Aurora Marques Cianciarullo - Cyntia Silva de Oliveira - Priscila Isabel Vicente - Dirce Sakauchi - Erica Akemi Kavati Sasaki

Human papillomavirus and induction of cervical cancer has been proved since 1974, but the suspicion of transient idiopathic infertility induction attributed to HPV has recently been addressed. In the 1920s, the first observations appeared that associated skin warts or mucosal lesions with an infectious agent, but there is recognition that the HPV virus is the main etiological factor of cervical neoplasia that began in the 1970s. In 1933, the first Papillomavirus was found in lesions and warts in rabbits, confirming the suspected infectious etiology of lesions and warts in animal species. There is a clear need for a more effective combat against the virus, which has periodically been correlated with new diseases that indiscriminately affect men, women, and children of all social classes. Recent technological advances have contributed to the improvement of experimental work tools, providing scientists with new horizons to be explored in the development of new products, free from serious side effects, due to genetic manipulation in the construction of expression vectors directed to therapeutic targets of interest. This book presents a review of the scientific literature to tell readers some of the natural history about HPV and the advances in terms of prophylaxis and minimally invasive therapy, aiming to eradicate the virus and treat infected patients, who developed cancer induced by HPV.

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Editora: EDITORA CRV
ISBN:978-65-251-5296-7
ISBN DIGITAL:978-65-251-5297-4
DOI: 10.24824/978652515296.7
Ano de edição: 2024
Distribuidora: EDITORA CRV
Número de páginas: 168
Formato do Livro: 16x23 cm
Número da edição:1

PRESENTATION - 13
HPV STRUCTURE - 19
HPV INFECTION – NATURAL HISTORY - 23
THERAPEUTIC TARGETS - 53
HOW TO MAKE A VACCINE AGAINST HPV - 57
NEW GENERATION OF PROPHYLACTIC AND THERAPEUTIC VACCINES FOR HPV - 71
PRECLINICAL STUDIES - 85
CLINICAL STUDIES - 87
COMBINATIONS OF MULTIPLE THERAPEUTIC MODALITIES - 89
VACCINE COMBINATIONS WITH STANDARD CARE THERAPEUTICS - 91
COMBINATION OF HPV VACCINES WITH OTHER THERAPIES - 93
COMMENTS ADDITIONAL AND OUTLOOKS - 97
CONCLUSION - 115
INDEX - 165

AURORA MARQUES CIANCIARULLO

Biologist graduated from Mackenzie University of São Paulo. Master's and Doctorate degrees in Cellular and Molecular Biology from IOC-FIOCRUZ-RJ. Post-Doctorate at DKFZ-Heidelberg-DE. Works at Butantan Institute-SP in alternative routes of infection in pathogen- host interaction and prophylactic and therapeutic vaccines for HPV-associated cancers.

CYNTIA SILVA DE OLIVEIRA

Biologist graduated from the São Paulo State University (UNESP). Master’s and Doctorate degrees in Molecular Biology from the Federal University of São Paulo (UNIFESP). Collaborating researcher at the Federal University of ABC (UFABC) in solid-phase peptide synthesis and structure-activity analysis of peptides in bacterial and tumor biological systems.

PRISCILA ISABEL VICENTE

Biologist graduated from the Federal University of São Carlos (UFSCAR). Specialization in Clinical and Toxicological Analysis at the Oswaldo Cruz Faculties of São Paulo (FOCSP) and in Biotechnology for Health: Vaccines and Biopharmaceuticals (Butantan Institute). Works in the areas of molecular biology and biotechnology focused mainly on the development of vaccines.

DIRCE SAKAUCHI

Pharmaceutical Sciences graduated from the Pontifical Catholic University of Campinas (PUC-Campinas-SP). Master's and doctorate degrees from the University of São Paulo (USP). Works at the Butantan Institute and conducts research with the human papillomavirus (HPV), to develop a vaccine against HPV.

ÉRICA AKEMI KAVATI SASAKI

Biologist graduated from the State University of Londrina-PR. Master's and Doctorate degrees in Biotechnology from the University of São Paulo (USP). Collaborating researcher at the Butantan Institute-SP in the areas of biotechnology, cellular and molecular biology in HPV, VLP, viral proteins, alternative routes of infection in the pathogen-host interaction, prophylactic and therapeutic vaccines for HPV-associated cancers.